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The Resource Junk DNA : a journey through the dark matter of the genome, Nessa Carey

Junk DNA : a journey through the dark matter of the genome, Nessa Carey

Creator
Author
Summary
"For decades after the identification of the structure of DNA, scientists focused only on genes, the regions of the genome that contain codes for the production of proteins. Other regions that make up 98 percent of the human genome were dismissed as "junk," sequences that serve no purpose. But researchers have recently discovered variations and modulations in this junk DNA that are involved with a number of intractable diseases. Our increasing knowledge of junk DNA has led to innovative research and treatment approaches that may finally ameliorate some of these conditions. Junk DNA can play vital and unanticipated roles in the control of gene expression, from fine-tuning individual genes to switching off entire chromosomes. These functions have forced scientists to revisit the very meaning of the word "gene" and have endangered a spirited scientific battle over whether or not this genomic "nonsense" is the source of human biological complexity. Drawing on her experience with leading scientific investigators in Europe and North America, Nessa Carey provides a clear and compelling introduction to junk DNA and its critical involvement in phenomena as diverse as genetic diseases, viral infections, sex determination in mammals, and evolution. We are only now unlocking the secrets of junk DNA, and Nessa Carey's book is an essential resource for navigating the history and controversies of this fast-growing, hotly disputed field." -- Publisher's description
Language
eng
Work
Publication
Extent
viii, 340 pages
Contents
  • An introduction to genomic dark matter
  • Why dark matter matters
  • When dark matter turns very dark indeed
  • Where did all the genes go?
  • Outstaying an invitation
  • Everything shrinks when we get old
  • Two is the perfect number
  • Painting with junk
  • Playing the long game
  • Adding colour to the dark matter
  • Why parents love junk
  • Junk with a mission
  • Switching it on, turning it up
  • No man's land
  • Project ENCODE : Big Science comes to junk DNA
  • Headless queens, strange cats, and portly mice
  • Lost in untranslation
  • Why LEGO is better than Airfix
  • Mini can be mighty
  • The drugs do work (sometimes)
  • Some light in the darkness
  • Appendix: Human diseases in which junk DNA has been implicated
Isbn
9780231170857
Instance
Label
Junk DNA : a journey through the dark matter of the genome
Title
Junk DNA
Title remainder
a journey through the dark matter of the genome
Statement of responsibility
Nessa Carey
Creator
Author
Subject
Language
eng
Summary
"For decades after the identification of the structure of DNA, scientists focused only on genes, the regions of the genome that contain codes for the production of proteins. Other regions that make up 98 percent of the human genome were dismissed as "junk," sequences that serve no purpose. But researchers have recently discovered variations and modulations in this junk DNA that are involved with a number of intractable diseases. Our increasing knowledge of junk DNA has led to innovative research and treatment approaches that may finally ameliorate some of these conditions. Junk DNA can play vital and unanticipated roles in the control of gene expression, from fine-tuning individual genes to switching off entire chromosomes. These functions have forced scientists to revisit the very meaning of the word "gene" and have endangered a spirited scientific battle over whether or not this genomic "nonsense" is the source of human biological complexity. Drawing on her experience with leading scientific investigators in Europe and North America, Nessa Carey provides a clear and compelling introduction to junk DNA and its critical involvement in phenomena as diverse as genetic diseases, viral infections, sex determination in mammals, and evolution. We are only now unlocking the secrets of junk DNA, and Nessa Carey's book is an essential resource for navigating the history and controversies of this fast-growing, hotly disputed field." -- Publisher's description
Cataloging source
YDXCP
http://library.link/vocab/creatorName
Carey, Nessa
Dewey number
572.86
Illustrations
illustrations
Index
index present
LC call number
  • QP624
  • QH447
LC item number
  • .C37 2015
  • .C37 2015
Literary form
non fiction
NLM call number
  • 2015 D-954
  • QU 460
http://library.link/vocab/subjectName
  • Genomics
  • Human genome
  • Eukaryotic cells
  • Recombinant DNA
  • Insertion elements, DNA
  • Non-coding RNA
  • Gene therapy
  • Eukaryotic cells
  • Gene therapy
  • Genomics
  • Human genome
  • Insertion elements, DNA
  • Non-coding RNA
  • Recombinant DNA
  • Genome, Human
  • DNA
  • Genomics
Label
Junk DNA : a journey through the dark matter of the genome, Nessa Carey
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
An introduction to genomic dark matter -- Why dark matter matters -- When dark matter turns very dark indeed -- Where did all the genes go? -- Outstaying an invitation -- Everything shrinks when we get old -- Two is the perfect number -- Painting with junk -- Playing the long game -- Adding colour to the dark matter -- Why parents love junk -- Junk with a mission -- Switching it on, turning it up -- No man's land -- Project ENCODE : Big Science comes to junk DNA -- Headless queens, strange cats, and portly mice -- Lost in untranslation -- Why LEGO is better than Airfix -- Mini can be mighty -- The drugs do work (sometimes) -- Some light in the darkness -- Appendix: Human diseases in which junk DNA has been implicated
Control code
ocn899332106
Dimensions
24 cm
Extent
viii, 340 pages
Isbn
9780231170857
Lccn
2014955417
Media category
unmediated
Media MARC source
rdamedia
Media type code
  • n
Other physical details
illustrations
System control number
  • (Sirsi) i9780231170840
  • (OCoLC)899332106
Label
Junk DNA : a journey through the dark matter of the genome, Nessa Carey
Publication
Bibliography note
Includes bibliographical references and index
Carrier category
volume
Carrier category code
  • nc
Carrier MARC source
rdacarrier
Content category
text
Content type code
  • txt
Content type MARC source
rdacontent
Contents
An introduction to genomic dark matter -- Why dark matter matters -- When dark matter turns very dark indeed -- Where did all the genes go? -- Outstaying an invitation -- Everything shrinks when we get old -- Two is the perfect number -- Painting with junk -- Playing the long game -- Adding colour to the dark matter -- Why parents love junk -- Junk with a mission -- Switching it on, turning it up -- No man's land -- Project ENCODE : Big Science comes to junk DNA -- Headless queens, strange cats, and portly mice -- Lost in untranslation -- Why LEGO is better than Airfix -- Mini can be mighty -- The drugs do work (sometimes) -- Some light in the darkness -- Appendix: Human diseases in which junk DNA has been implicated
Control code
ocn899332106
Dimensions
24 cm
Extent
viii, 340 pages
Isbn
9780231170857
Lccn
2014955417
Media category
unmediated
Media MARC source
rdamedia
Media type code
  • n
Other physical details
illustrations
System control number
  • (Sirsi) i9780231170840
  • (OCoLC)899332106

Subject

Library Locations

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